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Target intelligence / Profile preview
B3GALT5 antisense RNA 1 (B3GALT5-AS1)
- Target
- B3GALT5-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
B3GALT5 antisense RNA 1 (B3GALT5-AS1) is a long non-coding RNA (lncRNA) transcribed antisense to the B3GALT5 gene. It is upregulated in gastric cancer and has been shown to promote tumor cell proliferation, invasion, migration, and angiogenesis while inhibiting apoptosis[1][2]. Functionally, B3GALT5-AS1 regulates the expression of its sense gene B3GALT5 by recruiting WDR5, which modifies chromatin (H3K4me3 at the B3GALT5 promoter region), impacting gene transcription[1]. Additionally, B3GALT5-AS1 binds CSNK2A1 and is implicated in the regulation of extracellular matrix remodeling and apoptosis in gastric cancer cells[2]. High expression of B3GALT5-AS1 correlates with advanced tumor stage, lymphatic metastasis, and poor prognosis in gastric cancer, and thus may serve as a disease biomarker[1][2]. There are currently no drugs approved to target this lncRNA directly.
- Other names
- C21orf88B3GALT5-AS1B3GALT5 antisense RNA 1B3GALT5 antisense gene protein 1Putative uncharacterized protein B3GALT5-AS1
02
Mechanism of action
no targeted therapies defined; the molecule acts by recruiting chromatin modifiers or by molecular interaction with proteins such as WDR5 and CSNK2A1
03
Biological functions
Regulation of gene expression (epigenetic regulation)Regulation of proliferationRegulation of cell invasion, migration, and metastasisRegulation of apoptosisModulation of angiogenesisChromatin modification via protein recruitment (WDR5)
04
Disease associations
Cancer (notably gastric cancer)
05
Biomarkers
High B3GALT5-AS1 expression as a biomarker for gastric cancer progression, prognosis, and metastasis
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