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Target intelligence / Profile preview
B7-H3 (CD276)
- Target
- CD276
- Molecular classification
- Immunoglobulin superfamily, B7 family, Type I transmembrane glycoprotein
01
Overview
B7-H3 (CD276) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily and the B7 family. It functions as both a costimulatory and coinhibitory molecule in T cell-mediated immune responses. B7-H3 is overexpressed in a wide range of human cancers and correlates with tumor progression, metastasis, and poor prognosis. It promotes tumor migration/invasion, enhances drug resistance, and shapes the tumor microenvironment to favor immune evasion. Therefore it is an attractive target for cancer immunotherapy using monoclonal antibodies to block its immunosuppressive effects within the tumor microenvironment.
- Other names
- CD276B7-H34Ig-B7-H3B7H3B7RP-2
02
Mechanism of action
Monoclonal antibodies aiming to block immunosuppressive effects within the tumor microenvironment.
03
Biological functions
Immune checkpoint regulationCostimulation of T cellsCoinhibition of T cellsRegulation of T cell proliferationRegulation of IFN-gamma productionRegulation of anti-tumor immunity
04
Disease associations
CancerTumor progressionMetastasisDrug resistance
05
Safety considerations
Limited expression on normal tissue minimizes off-target effects, but potential for immune-related adverse events remains.
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