Molecular Classification
Immunoglobulin superfamily, B7 family, Type I transmembrane protein
Other Names
CD276
Disease Roles
Cancer

B7-H3 Protein Overview

B7-H3/CD276 is a multifunctional immune checkpoint molecule with complex roles spanning immunoregulation and direct promotion of malignancy. Its restricted expression pattern makes it an attractive target for next-generation cancer immunotherapies currently under clinical investigation. However, further research into its ligands/receptors and signaling pathways remains necessary for fully realizing its therapeutic potential.

Mechanism of Action

Monoclonal antibody, Antibody-drug conjugate, CAR-T cell therapy, Nanobody-based approach

Biological Functions

Immune checkpoint regulation
T cell activation/proliferation modulation
Angiogenesis promotion
Epithelial-to-mesenchymal transition facilitation
Tumor metabolism modulation

Disease Associations

Cancer

Safety Considerations

  • Potential for off-target effects due to B7-H3 expression in some normal tissues
  • Immune-related adverse events associated with immune checkpoint blockade

Interacting Drugs

Enoblituzumab
MGA271
MGC018

Associated Biomarkers

Biomarker
B7-H3 expression level in tumor tissue