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Target intelligence / Profile preview
B7-H3 Protein (CD276)
- Target
- CD276
- Molecular classification
- Immunoglobulin superfamily, B7 family, Type I transmembrane protein
01
Overview
B7-H3/CD276 is a multifunctional immune checkpoint molecule with complex roles spanning immunoregulation and direct promotion of malignancy. Its restricted expression pattern makes it an attractive target for next-generation cancer immunotherapies currently under clinical investigation. However, further research into its ligands/receptors and signaling pathways remains necessary for fully realizing its therapeutic potential.
- Other names
- CD276
02
Mechanism of action
Monoclonal antibody, Antibody-drug conjugate, CAR-T cell therapy, Nanobody-based approach
03
Biological functions
Immune checkpoint regulationT cell activation/proliferation modulationAngiogenesis promotionEpithelial-to-mesenchymal transition facilitationTumor metabolism modulation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to B7-H3 expression in some normal tissuesImmune-related adverse events associated with immune checkpoint blockade
06
Interacting drugs
Enoblituzumab
2 more in the full profile.
07
Biomarkers
B7-H3 expression level in tumor tissue
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