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Target intelligence / Profile preview
B7-H4 Protein (B7-H4)
- Target
- B7-H4
- Molecular classification
- B7 family protein, Type I transmembrane protein, Immunoregulatory protein
01
Overview
B7-H4 (VTCN1) is an immune checkpoint protein belonging to the B7 family. It is a type I transmembrane protein that acts as a co-inhibitory ligand for activated lymphocytes, suppressing T cell function by inhibiting proliferation, reducing cytokine production, and/or inducing apoptosis. B7-H4 is overexpressed in various cancers, contributing to tumor immune evasion and is considered a promising target for cancer immunotherapy. Its receptor on T cells is currently unknown.
- Other names
- VTCN1B7xB7S1
02
Mechanism of action
Inhibition of T-cell activation and proliferation via interaction with an unknown receptor; direct anti-tumor activity; enhancement of anti-tumor immunity.
03
Biological functions
Immune checkpoint inhibitionT cell suppressionRegulation of T cell proliferationRegulation of cytokine productionInduction of apoptosis in T cells
04
Disease associations
CancerImmune evasionOvarian cancerBreast cancerLung cancerRenal cell carcinoma
05
Safety considerations
Potential for immune-related adverse eventsOn-target, off-tumor toxicity due to B7-H4 expression on certain immune cells
06
Interacting drugs
Monoclonal antibodies against B7-H4 (experimental)
07
Biomarkers
B7-H4 expression level in tumor tissueSoluble B7-H4 levels in serum/plasma
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