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Target intelligence / Profile preview
B7 Homolog 3 Protein (B7-H3)
- Target
- B7-H3
- Molecular classification
- B7 family, Immunoglobulin superfamily, Type I transmembrane glycoprotein, Immune checkpoint
01
Overview
B7 homolog 3 protein (B7-H3), also known as CD276, is a member of the B7 family of immune regulatory proteins. It functions primarily as an immune checkpoint molecule and plays complex roles in modulating immune responses, particularly within the tumor microenvironment. It acts as both a costimulatory and coinhibitory molecule, promoting tumor cell migration, invasion, angiogenesis, chemoresistance, and epithelial-to-mesenchymal transition. B7-H3 is overexpressed in many solid tumors and correlates with poor prognosis, making it a promising target for immunotherapy.
- Other names
- CD276
02
Mechanism of action
Monoclonal antibodies targeting B7-H3; Antibody-drug conjugates targeting B7-H3; CAR-T cell therapies targeting B7-H3-expressing tumors
03
Biological functions
Immune checkpoint inhibitionT cell costimulationTumor cell migrationInvasionAngiogenesisChemoresistanceEpithelial-to-mesenchymal transitionModulation of tumor metabolism
04
Disease associations
Cancer
05
Safety considerations
Potential for immune-related adverse eventsOn-target, off-tumor toxicity due to B7-H3 expression on normal tissues
06
Interacting drugs
Enoblituzumab/MGA271
1 more in the full profile.
07
Biomarkers
Soluble B7-H3 in serum
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