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Target intelligence / Profile preview
B7 Homolog 4 Protein (B7-H4)
- Target
- B7-H4
- Molecular classification
- Immunoglobulin superfamily, B7 family, Type I transmembrane glycoprotein
01
Overview
B7-H4 protein is a member of the B7 family of immunomodulatory proteins. It is a type I transmembrane glycoprotein that acts as a co-inhibitory molecule for T-cell responses. It is highly upregulated in various cancers and plays a role in tumor immune evasion.
- Other names
- B7xB7S1VTCN1
02
Mechanism of action
Inhibits T-cell effector function by inducing cell cycle arrest, decreasing proliferation, and reducing IL‑2 production; reverse signaling mechanisms that may induce apoptosis or arrest in expressing cells.
03
Biological functions
Immune responseT-cell inhibitionCell cycle arrestRegulation of T-cell immunityTumor immune evasion
04
Disease associations
CancerOvarian CancerLung CancerRenal Cell CarcinomaRheumatoid Arthritis
05
Safety considerations
Potential for off-target effects on immune cellsRisk of exacerbating autoimmune diseasesImmune-related adverse events
06
Interacting drugs
Monoclonal antibodies
2 more in the full profile.
07
Biomarkers
B7-H4 expression in tumorsSoluble B7-H4 levels in serum
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