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Target intelligence / Profile preview
HERV-H LTR-associating protein 2 (HHLA2)
- Target
- HHLA2
- Molecular classification
- B7 family of immune regulatory ligands, Type I transmembrane protein
01
Overview
HERV-H LTR-associating protein 2 (HHLA2) is an immunoregulatory ligand belonging to the B7 family. It is highly relevant as a prognostic marker across several cancers and as an emerging therapeutic target due to its role as an inhibitory immune checkpoint molecule predominantly active within the tumor microenvironment. HHLA2 inhibits T cell proliferation and cytokine production, making it a potential target for cancer immunotherapy and autoimmune disease treatment.
- Other names
- B7 homolog 7B7H7
02
Mechanism of action
Inhibition of T cell proliferation and cytokine production through binding to a putative receptor on T cells and APCs, acting as an immune checkpoint.
03
Biological functions
Immune modulationInhibition of T cell proliferationRegulation of cytokine productionSignaling receptor binding
04
Disease associations
CancerAutoimmune diseases
05
Safety considerations
Potential for immune-related adverse eventsLimited expression in normal tissues but still potential for off-target effects.
06
Biomarkers
HHLA2 expression levels in tumors
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