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Target intelligence / Profile preview
B7-homologue 3 (B7-H3)
- Target
- B7-H3
- Molecular classification
- Immunoglobulin superfamily, B7 ligand family, Type I transmembrane glycoprotein
01
Overview
B7-H3, also known as CD276, is a type I transmembrane glycoprotein belonging to the B7 family of immune regulatory ligands. It acts as an immune checkpoint molecule that inhibits T cell activation and proliferation. B7-H3 is notably overexpressed in many cancer types and correlates with poor prognosis. Targeting B7-H3 with antibody-based immunotherapies is being explored as a therapeutic strategy.
- Other names
- CD276
02
Mechanism of action
Antibody-based therapies targeting B7-H3 on tumor cells to induce anti-tumor immune responses or directly inhibit tumor progression.
03
Biological functions
Immune checkpoint regulationInhibition of T-cell activation/proliferationPromotion of tumor progressionRegulation of T cell lymphocytesAngiogenesisEndothelial-to-mesenchymal transition (EMT)Tumor metabolism
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to B7-H3 expression in some normal tissues.
06
Biomarkers
B7-H3 expression level in tumor tissue
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