Target intelligence / Profile preview

B7.1 Costimulatory Molecule (None)

Target: None
Molecular classification: Integral membrane glycoprotein, Receptor

Overview

B7.1, also known as CD80, is an integral membrane protein that functions as a costimulatory molecule on antigen-presenting cells (APCs). It provides a crucial second signal for T cell activation during antigen presentation by interacting with CD28 (stimulatory) and CTLA-4 (inhibitory) on T cells. Its expression and function are implicated in autoimmunity and cancer immunotherapy.

Other names: CD80B7-1

Mechanism of action

Blocking CTLA‑4 allows sustained costimulation through CD28/B71 interactions, enhancing antitumor immunity.

Biological functions

Immune responseT cell activationCostimulationAntigen presentation

Disease associations

Autoimmune diseasesCancer

Safety considerations

Autoimmunity risk if misexpressed

Interacting drugs

CTLA-4 inhibitors

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