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Bacillus velezensis is an aerobic, Gram-positive, endospore-forming bacterium within the genus Bacillus. It was defined as a distinct species following phylogenomic reclassification, absorbing several previously independent Bacillus species. Strains of B. velezensis are widely recognized for their production of bioactive compounds (including lipopeptides such as surfactin, iturin, fengycin, and polyketides like bacillaene, difficidin, and macrolactin) which confer broad-spectrum antimicrobial activity against bacterial, fungal, and nematode pathogens of plants. This bacterium promotes plant growth both directly (e.g., phytohormone production, nitrogen fixation) and indirectly (disease suppression), and it can trigger plant immune responses (induced systemic resistance). B. velezensis is used chiefly as a biocontrol agent in agriculture, rather than as a human therapeutic target.
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