Bacteria within wound biofilm

Bacteria within wound biofilm represent a complex, sessile community of microorganisms encased in a self-produced extracellular polymeric substance (EPS) matrix, which significantly complicates the treatment of chronic wounds (Metcalf et al., 2014, PubMed). This matrix, composed of polysaccharides, proteins, and extracellular DNA, provides a physical and chemical barrier that protects bacteria from the host immune system and increases their resistance to conventional antimicrobial agents by up to 1,000-fold compared to planktonic cells (Percival et al., 2012, Wound Repair Regen). Biofilms are a primary driver of chronicity in wounds such as diabetic foot ulcers, pressure ulcers, and venous leg ulcers, where they maintain a state of persistent inflammation and prevent re-epithelialization (James et al., 2008, Wound Repair Regen). Therapeutic strategies targeting wound biofilms involve a combination of physical debridement and the use of specialized anti-biofilm agents, including silver-based dressings, iodine-releasing compounds, and enzymatic disruptors that degrade the EPS matrix (Schultz et al., 2017, Wound Care Canada). Effective management of these microbial communities is essential for transitioning a chronic wound into a healing state and preventing systemic complications like sepsis (Attinger & Wolcott, 2012, Clin Podiatr Med Surg).

Other names

Wound biofilmBacterial biofilm in woundsChronic wound biofilmBiofilm-associated wound infectionMicrobial biofilm

Disruption of the extracellular polymeric substance (EPS) matrix, inhibition of bacterial protein synthesis, disruption of cell membranes, and interference with quorum sensing signaling to restore antibiotic susceptibility and promote wound healing.