Molecular Classification
Ribosomal RNA, Non-coding RNA
Other Names
23S ribosomal RNA, Large subunit ribosomal RNA (bacterial), 23S rRNA (50S subunit)
Disease Roles
InfectionAntibiotic resistance

Bacterial 23S Ribosomal RNA Overview

Bacterial 23S ribosomal RNA (rRNA) is a major structural and functional component of the large (50S) subunit of the prokaryotic ribosome. It is essential for catalyzing peptide bond formation and serves as a primary target for several classes of antibiotics.

Mechanism of Action

Inhibition of bacterial translation by blocking peptide bond formation or interfering with tRNA positioning on the 23S rRNA.

Biological Functions

Peptide bond formation
Ribosome assembly
tRNA binding
Translation

Disease Associations

Infection
Antibiotic resistance

Safety Considerations

  • Potential for antibiotic resistance development
  • Off-target effects of antibiotics

Interacting Drugs

Macrolides
Chloramphenicol
Clindamycin
Pleuromutilins
Oxazolidinones