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Bacterial 23S Ribosomal RNA (23S rRNA)
- Target
- 23S rRNA
- Molecular classification
- Ribosomal RNA, Non-coding RNA
01
Overview
Bacterial 23S ribosomal RNA (rRNA) is a major structural and functional component of the large (50S) subunit of the prokaryotic ribosome. It is essential for catalyzing peptide bond formation and serves as a primary target for several classes of antibiotics.
- Other names
- 23S ribosomal RNALarge subunit ribosomal RNA (bacterial)23S rRNA (50S subunit)
02
Mechanism of action
Inhibition of bacterial translation by blocking peptide bond formation or interfering with tRNA positioning on the 23S rRNA.
03
Biological functions
Peptide bond formationRibosome assemblytRNA bindingTranslation
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Potential for antibiotic resistance developmentOff-target effects of antibiotics
06
Interacting drugs
Macrolides
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