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Target intelligence / Profile preview
Bacterial 50S Ribosomal Subunit (50S Ribosomal Subunit)
- Target
- 50S Ribosomal Subunit
- Molecular classification
- Ribonucleoprotein, Ribosomal Subunit
01
Overview
The bacterial 50S ribosomal subunit is the larger component of the prokaryotic 70S ribosome, essential for protein synthesis. It is composed of 23S rRNA, 5S rRNA, and approximately 31 structural proteins. Its primary function is to catalyze peptide bond formation during translation. Many antibiotics target the 50S subunit to inhibit bacterial protein synthesis.
- Other names
- Large ribosomal subunit50S ribosomeBacterial ribosome large subunit
02
Mechanism of action
Inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit and interfering with peptidyl transferase activity or blocking the peptide exit tunnel.
03
Biological functions
Protein synthesisPeptide bond formationtRNA bindingTranslation
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistancePotential for off-target effects (although designed to be selective for bacterial ribosomes)Drug interactions
06
Interacting drugs
Macrolides
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