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Bacterial Adhesion to Urothelial Cells
- Molecular classification
- Other
01
Overview
Bacterial adhesion to urothelial cells is a critical early event in the pathogenesis of urinary tract infections (UTIs). This process enables uropathogenic bacteria, most notably *Escherichia coli* (UPEC), to colonize and invade the urinary tract, leading to infection. The interaction involves specific bacterial surface structures called adhesins that recognize and bind to receptors on the surface of urothelial cells. Key bacterial adhesins include Type 1 fimbriae (FimH adhesin) which binds to uroplakins, and P pili (PapG adhesin).
02
Mechanism of action
Inhibition of bacterial adhesion to urothelial cells, competition for binding sites
03
Biological functions
AdhesionColonizationInitiation of infection
04
Disease associations
Urinary Tract Infection
05
Safety considerations
Development of resistance to anti-adhesive therapiesPotential disruption of normal flora
06
Interacting drugs
D-mannose
2 more in the full profile.
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