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Bacterial Biofilm (N/A)
- Target
- N/A
- Molecular classification
- Extracellular matrix, Microbial community
01
Overview
A bacterial biofilm is a complex, structured community of microorganisms, primarily bacteria, that are embedded within a self-produced matrix of extracellular polymeric substances (EPS). This matrix provides structural integrity and protection, making biofilms highly resistant to antibiotics and host immune responses. Targeting biofilms aims to disrupt their formation, degrade the matrix, or enhance antibiotic penetration to eradicate persistent infections.
- Other names
- Microbial biofilmBiofilms
02
Mechanism of action
Disrupting biofilm formation, degrading EPS matrix, inhibiting quorum sensing, increasing antibiotic penetration, promoting biofilm dispersal
03
Biological functions
Protection from environmental threatsEnhanced tolerance/resistance to antimicrobial agentsHorizontal gene transferAdhesionQuorum sensing
04
Disease associations
InfectionChronic infectionsPersistent infections
05
Safety considerations
Development of antibiotic resistanceIncomplete eradication leading to recurrenceNon-specific targeting affecting beneficial bacteriaDelivery challenges to penetrate the biofilm matrix
06
Interacting drugs
Antibiotics
2 more in the full profile.
07
Biomarkers
Biofilm-specific EPS componentsQuorum sensing moleculesBiofilm-associated gene expression
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