Bacterial Biofilm Disruption (N/A)

Bacterial biofilm disruption is a therapeutic strategy that aims to break down the protective matrix of bacterial biofilms, rendering the embedded bacteria more susceptible to antibiotics and host immune defenses. It is particularly relevant in chronic respiratory infections associated with cystic fibrosis, where biofilms contribute to persistent inflammation and antimicrobial resistance. Approaches include degrading matrix components like exopolysaccharides, eDNA, and structural proteins such as DNABII, as well as interfering with quorum sensing and inhibiting matrix synthesis.

Other names

Biofilm EradicationBiofilm DegradationBiofilm InterferenceExtracellular matrix disruption

Disrupting the biofilm matrix to expose bacteria to antibiotics and immune cells.