Bacterial biofilm growth

A bacterial biofilm is a structured community of bacterial cells surrounded by a self-produced polymeric matrix (composed primarily of polysaccharides, proteins, and extracellular DNA) that adheres to biotic or abiotic surfaces[1][3][4]. Biofilm formation is a multistep process involving initial planktonic bacterial attachment, microcolony formation, matrix production, and ultimately maturation and dispersal[1][4][7]. Within a biofilm, bacteria become highly resistant to antibiotics and host immune response, largely due to the physical barrier of the matrix, altered metabolic states (including dormant persister cells), and enhanced horizontal gene transfer, making biofilms a key driver of chronic and device-related infections and a major obstacle in infection eradication[5][4][6].

Other names

BiofilmBacterial biofilmsMicrobial biofilm

Inhibition of bacterial adhesion; Disruption of matrix (e.g., DNase degrades extracellular DNA); Quorum sensing interference; Killing/detachment of sessile cells; Targeting dormant persister cells