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Bacterial Biofilm Structural Lattice (N/A)
- Target
- N/A
- Molecular classification
- Extracellular matrix, Polysaccharide, DNA, Protein complex
01
Overview
The bacterial biofilm structural lattice is a complex, three-dimensional network composed primarily of extracellular DNA (eDNA), proteins (including DNABII family members), and exopolysaccharides. This matrix provides mechanical stability, protects bacteria from environmental stressors, and facilitates cell-to-cell communication within the biofilm. Targeting components of this lattice is a promising strategy for disrupting biofilms and enhancing the efficacy of antimicrobial treatments.
- Other names
- Biofilm matrixEPS matrixeDNA latticeExtracellular polymeric substance matrix
02
Mechanism of action
Enzymatic degradation of eDNA; Disruption of protein-DNA interactions; Degradation of polysaccharides; Chelation of divalent cations
03
Biological functions
Mechanical supportProtection from environmental stressorsCell-to-cell communicationHorizontal gene transferBiofilm formationAdhesion
04
Disease associations
InfectionAntibiotic resistanceChronic infectionsMedical device-related infections
05
Safety considerations
Potential for off-target effects with broad-spectrum nucleasesDevelopment of resistance to biofilm-disrupting agentsPotential for release of viable bacteria during disruption, leading to dissemination of infection
06
Interacting drugs
HJ-specific endonucleases (RuvABC or RusA)
5 more in the full profile.
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