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Target intelligence / Profile preview
Bacterial Capsular Polysaccharides (CPS)
- Target
- CPS
- Molecular classification
- Polysaccharide, Glycoconjugate, Antigen
01
Overview
Bacterial capsular polysaccharides (CPS) are long-chain carbohydrate polymers that form a dense capsule surrounding the cell wall of many bacteria. They are composed of repeating units of sugars and exhibit high structural diversity. CPS protect bacteria from environmental stresses, host immune defenses, and bacteriophages, acting as a virulence factor and contributing to biofilm formation. CPS diversity is used for serotyping bacterial isolates, and they are targets for vaccine development and phage therapy.
- Other names
- Capsular PolysaccharidesCapsular Polysaccharide AntigensBacterial CapsulesK antigensKL types
02
Mechanism of action
Vaccine antigen; Target of phage depolymerases
03
Biological functions
Protection from phagocytosisProtection from complement activationBiofilm formationAdhesionImmune evasionDesiccation resistanceBacteriophage resistance
04
Disease associations
InfectionBacterial virulenceChronic infections
05
Safety considerations
Potential for serotype replacement after vaccinationStructural complexity hindering vaccine development for all serotypesVariability limits broad-spectrum targeting
06
Biomarkers
Capsule serotype (for epidemiological typing)Capsule presence/absence
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