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Bacterial Cell Wall Pentaglycyl Peptide Bridging Segment (Pentaglycyl Bridge)
- Target
- Pentaglycyl Bridge
- Molecular classification
- Peptide, Cell Wall Component
01
Overview
The bacterial cell wall pentaglycyl peptide bridging segment is a structural component found in the peptidoglycan layer of certain Gram-positive bacteria, notably *Staphylococcus aureus*. This segment, consisting of five glycine residues, connects peptide side chains attached to N-acetylmuramic acid (MurNAc) residues, providing strength and rigidity to the cell wall. It's a key target for antibiotics like lysostaphin and beta-lactams, and variations contribute to antibiotic resistance.
- Other names
- Pentaglycine bridgePeptidoglycan interpeptide bridgeGlycine cross-linkCell wall cross-linking peptide
02
Mechanism of action
Inhibition of cross-linking; cleavage of pentaglycine bonds.
03
Biological functions
Cell wall integrityPeptidoglycan cross-linkingStructural supportResistance to osmotic lysis
04
Disease associations
Bacterial infectionAntibiotic resistance
05
Safety considerations
Development of resistanceOff-target effects of lysostaphin
06
Interacting drugs
Lysostaphin
2 more in the full profile.
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