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Bacterial Cell Wall Peptide Bridging Segment
- Molecular classification
- Peptide, Cell Wall Component
01
Overview
The bacterial cell wall peptide bridging segment, also known as the peptide cross-bridge or interpeptide bridge, is a short peptide sequence that connects the stem peptides of peptidoglycan strands, primarily in Gram-positive bacteria. This segment is crucial for the structural integrity and rigidity of the bacterial cell wall. It's formed by transpeptidases which are the target of beta-lactam antibiotics.
- Other names
- Peptide Cross-BridgeInterpeptide BridgePeptidoglycan Crosslink
02
Mechanism of action
Inhibition of transpeptidases (penicillin-binding proteins) involved in cross-linking
03
Biological functions
Cell wall integrityCross-linking of peptidoglycanStructural supportResistance to osmotic lysis
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Development of antibiotic resistanceChanges in cell wall structure affecting antibiotic susceptibility
06
Interacting drugs
Beta-lactam antibiotics
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