Bacterial citric acid cycle (TCA cycle (bacterial))

The **bacterial citric acid cycle** (also known as the Krebs cycle or tricarboxylic acid (TCA) cycle) is a core metabolic pathway in bacteria that oxidizes acetyl-CoA to carbon dioxide, producing energy in the form of ATP, and generating NADH and FADH₂ for cell respiration[1][3][5][6][8]. In bacteria, the cycle occurs in the cytosol and is essential for energy production and biosynthesis of key intermediates. Variations and regulatory alterations of this pathway play a significant role in bacterial physiology, including the development of metabolic-based antibiotic tolerance[2][4][10]. The pathway itself is too broad to be considered a conventional drug target; however, individual enzymes within the pathway (such as isocitrate dehydrogenase, citrate synthase, etc.) have been studied as potential antimicrobial targets.

Other names

Krebs cycle (bacterial)Tricarboxylic acid cycle (bacterial)Szent–Györgyi–Krebs cycle (bacterial)

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