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Target intelligence / Profile preview
Bacterial DNA-dependent RNA polymerase beta subunit (β subunit)
- Target
- β subunit
- Molecular classification
- Enzyme, RNA Polymerase, Transcription factor subunit
01
Overview
The bacterial DNA-dependent RNA polymerase beta subunit (β subunit) is a core component of the multisubunit enzyme responsible for transcribing DNA into RNA in bacteria. Encoded by the rpoB gene, it is a crucial part of the RNA polymerase complex (α2ββ′ω). The β subunit contains the catalytic center for RNA synthesis and interacts with both template DNA and nascent RNA. Mutations in rpoB can confer resistance to antibiotics like rifampicin, making it a clinically significant target.
- Other names
- rpoBBeta subunit of bacterial RNAP
02
Mechanism of action
Inhibition of bacterial RNA polymerase
03
Biological functions
TranscriptionRNA synthesisGene expression
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Development of antibiotic resistance
06
Interacting drugs
Rifampicin
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