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Target intelligence / Profile preview
Bacterial DNA topoisomerase IV (TopoIV)
- Target
- TopoIV
- Molecular classification
- Enzyme, DNA topoisomerase, Type II topoisomerase
01
Overview
Bacterial DNA topoisomerase IV (TopoIV) is an essential type II DNA topoisomerase in bacteria. It is a heterotetrameric enzyme composed of ParC and ParE subunits, forming an A2B2 complex. TopoIV primarily functions in decatenating interlinked daughter chromosomes after DNA replication and relaxing positive supercoils. It is a validated antibacterial drug target, inhibited by quinolones like ciprofloxacin, leading to bacterial cell death due to chromosome segregation failure.
- Other names
- Topo 4Type II topoisomerases subfamily
02
Mechanism of action
Inhibition of DNA breakage and rejoining, leading to chromosome segregation failure.
03
Biological functions
DNA decatenationRelaxation of positive supercoilsChromosome segregationDNA topology management
04
Disease associations
Infection
05
Interacting drugs
Ciprofloxacin
2 more in the full profile.
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