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Target intelligence / Profile preview
Bacterial DNABII Protein (DNABII)
- Target
- DNABII
- Molecular classification
- Nucleoid-associated protein, DNA-binding protein
01
Overview
Bacterial DNABII proteins are a family of DNA-binding proteins universally expressed by eubacteria. They play a critical role in bacterial chromosome organization and biofilm formation by stabilizing the extracellular DNA (eDNA) lattice. Targeting DNABII can disrupt biofilms and increase bacterial susceptibility to antibiotics.
- Other names
- Integration Host FactorIHFHistone-like protein HUHU
02
Mechanism of action
Disruption of eDNA lattice in biofilms, destabilizing the biofilm matrix and increasing susceptibility to antibiotics and immune clearance.
03
Biological functions
Nucleoid structuringChromosome organizationDNA condensationBiofilm stabilizationeDNA lattice stabilizationReplication supportGene regulation support
04
Disease associations
InfectionBiofilm-associated infections
05
Safety considerations
Potential off-target effects on host DNADevelopment of resistanceImmunogenicity of antibodies or peptides
06
Interacting drugs
Antibodies against DNABII
2 more in the full profile.
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