Bacterial enzymes of aerobic energy metabolism

Bacterial enzymes of aerobic energy metabolism refer to the collective group of protein complexes that drive the respiratory electron transport chain and oxidative phosphorylation in bacteria (oup.com, portlandpress.com). This target entry encompasses multiple distinct enzymes, including NADH dehydrogenases (NDH-1 and NDH-2), succinate dehydrogenase, the cytochrome bcc complex, terminal oxidases, and the F1F0-ATP synthase (oup.com, asm.org). These components work in concert to generate a proton motive force across the bacterial membrane, which is then utilized to produce ATP, the primary energy currency for cellular processes (asm.org, walshmedicalmedia.com). In pathogens like Mycobacterium tuberculosis, these pathways are critical for survival during both active replication and dormant persistence, making them attractive targets for drug development (oup.com). The diarylquinoline bedaquiline, which inhibits ATP synthase, was the first drug in this class to receive FDA approval for multidrug-resistant tuberculosis (asm.org, nih.gov). Other candidates, such as telacebec (Q203), target the cytochrome bcc complex to disrupt respiration (portlandpress.com). A primary challenge in targeting these enzymes is achieving sufficient selectivity to avoid cross-reactivity with human mitochondrial respiratory complexes, thereby minimizing potential host toxicity (oup.com).

Other names

Bacterial respiratory chain enzymesBacterial oxidative phosphorylation machineryBacterial aerobic respiration systemBacterial electron transport chain complexesBacterial bioenergetics targets

Inhibition of bacterial oxidative phosphorylation and ATP synthesis by blocking specific respiratory chain complexes or the ATP synthase enzyme, leading to energy depletion and loss of membrane potential.