Molecular Classification
Enzyme, ATP synthase subunit
Other Names
bacterial F-type ATPase, bacterial F0F1-ATPase, bacterial FoF₁-ATPase, bacterial F₁ sector
Disease Roles
Infection

Bacterial F1-ATPase Overview

Bacterial F1-ATPase is the soluble, catalytic sector of the bacterial ATP synthase. It is responsible for the synthesis and hydrolysis of adenosine triphosphate (ATP), a central molecule in cellular energy metabolism. The enzyme harnesses energy from a transmembrane electrochemical gradient to drive ATP production from adenosine diphosphate (ADP) and inorganic phosphate. It is a validated drug target for antibacterial treatment, but selectivity over mitochondrial homologs remains challenging. The F1 sector has subunit composition α3β3γδε.

Mechanism of Action

Inhibition of ATP synthesis

Biological Functions

ATP synthesis
ATP hydrolysis
Proton pumping (reverse function)

Disease Associations

Infection

Safety Considerations

  • Selectivity over mitochondrial ATP synthases