Bacterial F1-ATPase (F1-ATPase)

Bacterial F1-ATPase is the soluble, catalytic sector of the bacterial ATP synthase. It is responsible for the synthesis and hydrolysis of adenosine triphosphate (ATP), a central molecule in cellular energy metabolism. The enzyme harnesses energy from a transmembrane electrochemical gradient to drive ATP production from adenosine diphosphate (ADP) and inorganic phosphate. It is a validated drug target for antibacterial treatment, but selectivity over mitochondrial homologs remains challenging. The F1 sector has subunit composition α3β3γδε.

Other names

bacterial F-type ATPasebacterial F0F1-ATPasebacterial FoF₁-ATPasebacterial F₁ sector

Inhibition of ATP synthesis