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Target intelligence / Profile preview
Bacterial Flagellum (N/A)
- Target
- N/A
- Molecular classification
- Macromolecular machine, Motor protein, Surface antigen
01
Overview
The bacterial flagellum is a complex, macromolecular nanomachine responsible for locomotion in many motile bacteria. It acts as a rotary motor organelle, propelling the bacterium through liquid environments by rotating a long helical filament. In addition to motility, some bacterial flagella can serve as sensory organelles and play roles in virulence and host-pathogen interactions. It is a target for the development of anti-infectives that aim to inhibit motility or block host-pathogen interactions.
- Other names
- FlagellumBacterial motility apparatus
02
Mechanism of action
Inhibition of flagellar assembly or function; disruption of bacterial motility; blocking host-pathogen interactions
03
Biological functions
MotilityChemotaxisSensory transductionAdhesion
04
Disease associations
InfectionBacterial colonizationBiofilm formationVirulence
05
Safety considerations
Potential for off-target effects on commensal bacteriaDevelopment of bacterial resistance to flagellum-targeting therapeuticsImmunogenicity of flagellin-based therapies
06
Interacting drugs
Flagellin-targeted antibodies
2 more in the full profile.
07
Biomarkers
Flagellin levels in serum or other biological fluids (for infection diagnosis)Flagellar gene expression levels (for monitoring virulence)
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