Bacterial Folic Acid Metabolism Enzyme

Bacterial folic acid metabolism involves a series of enzymes that synthesize and modify folate derivatives, which are essential for one-carbon transfer reactions in nucleotide and amino acid biosynthesis. The pathway is critical for bacterial growth and survival, making its enzymes important targets for antibiotics. Key enzymes include dihydrofolate reductase (DHFR), dihydropteroate synthase (DHPS), and thymidylate synthase (TYMS). Inhibition of these enzymes disrupts nucleotide and amino acid synthesis, leading to impaired cell division or death. Resistance can arise through mutations or acquisition of alternative enzyme variants.

Other names

Folate biosynthesis pathway enzymes (bacterial)

Inhibition of bacterial folic acid metabolism