Bacterial lysis of Pseudomonas aeruginosa

Bacterial lysis of Pseudomonas aeruginosa is a biological process characterized by the disintegration of the bacterial cell envelope, resulting in the release of intracellular contents and cell death. This phenomenon is the intended therapeutic outcome of various antimicrobial interventions used to treat infections caused by this Gram-negative opportunistic pathogen (Source: StatPearls, NBK557440). The process can be triggered by antibiotics such as beta-lactams, which inhibit penicillin-binding proteins (PBPs) to disrupt peptidoglycan synthesis, or polymyxins, which target the lipopolysaccharide (LPS) in the outer membrane (Source: PubMed, PMID: 29445114). Additionally, bacteriophage-derived endolysins are being explored as highly specific agents to induce lysis by degrading the bacterial cell wall (Source: Frontiers in Microbiology, 2020). While effective for pathogen clearance, rapid lysis of P. aeruginosa can lead to the massive release of endotoxins, potentially inducing a severe systemic inflammatory response or septic shock in the host (Source: PubMed, PMID: 11486361). Because it describes a physiological event rather than a specific protein or nucleic acid, it is classified as a biological process or mechanism of action rather than a discrete molecular target.

Other names

Pseudomonas aeruginosa lysisBacteriolysis of P. aeruginosaCell wall disruption of PseudomonasPseudomonas cell death

Inhibition of peptidoglycan synthesis, disruption of the bacterial outer membrane, or enzymatic degradation of the cell wall by lysins.