Target intelligence / Profile preview

Bacterial Metabolism in Dental Plaque

Molecular classification
Metabolic Process, Microbial Metabolism, Biofilm Metabolism
01

Overview

Bacterial metabolism in dental plaque encompasses the collective metabolic activities of the diverse microbial community within dental biofilms. This complex process involves the breakdown of dietary carbohydrates and endogenous substrates, leading to the production of acids and other metabolites that contribute to the development of dental caries and other oral diseases. The composition and activity of the plaque microbiome are influenced by factors such as diet, saliva, and interspecies interactions.

Other names
Plaque MetabolismDental Plaque MetabolismOral Biofilm MetabolismMicrobial Metabolism in Dental Plaque
02

Mechanism of action

Varies depending on the specific intervention: Antimicrobials target bacterial cell structure/function; Fluoride inhibits demineralization and promotes remineralization; Xylitol is non-fermentable and disrupts bacterial metabolism; Probiotics introduce beneficial bacteria; Prebiotics promote the growth of beneficial bacteria.

03

Biological functions

Nutrient acquisitionEnergy productionWaste product removalBiofilm formation and maintenancepH regulationInterspecies communication and cooperation
04

Disease associations

Dental cariesPeriodontal diseaseGingivitisOral infections
05

Safety considerations

Antibiotic resistanceDisruption of oral microbiome balancePotential for adverse effects from antimicrobials or other interventions
06

Interacting drugs

Antimicrobials (e.g., chlorhexidine)

4 more in the full profile.

07

Biomarkers

Plaque pHLevels of specific bacterial species (e.g., *Streptococcus mutans*, *Lactobacillus* spp.)Concentration of organic acids (e.g., lactic acid)Enzyme activity (e.g., glycosyltransferases)

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