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Target intelligence / Profile preview
Bacterial Nitroreductase Enzyme (NTR)
- Target
- NTR
- Molecular classification
- Enzyme, Oxidoreductase, FMN-dependent enzyme
01
Overview
Bacterial nitroreductases are a diverse family of flavin mononucleotide (FMN)-dependent oxidoreductase enzymes predominantly found in bacteria. These enzymes catalyze the reduction of nitro groups on aromatic and heterocyclic compounds, converting them into amino or hydroxylamino derivatives. They are used in prodrug activation for cancer therapy, cell ablation models, bioremediation, and imaging applications. Engineered variants exist with enhanced catalytic efficiency and altered substrate specificity.
02
Mechanism of action
Reduction of nitro groups on aromatic and heterocyclic compounds
03
Biological functions
CatalysisProdrug activationPollutant degradationElectron transfer
04
Disease associations
CancerInfection
05
Safety considerations
Potential for off-target effectsImmunogenicity of engineered variantsOxygen sensitivity (for some types)Reactive oxygen species production (for some types)
06
Interacting drugs
CB1954
1 more in the full profile.
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