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Bacterial O-antigen (O-antigen)
- Target
- O-antigen
- Molecular classification
- Polysaccharide, Lipopolysaccharide component
01
Overview
The bacterial O-antigen is a highly variable, repetitive polysaccharide chain extending from the lipopolysaccharide (LPS) molecule on the surface of Gram-negative bacteria. It serves as a major antigenic determinant and is targeted by the host immune system. Its variability between strains allows for serotyping and contributes to immune evasion, making it a key factor in bacterial pathogenesis and vaccine development.
- Other names
- O-specific polysaccharideO-polysaccharideLPS O-antigen
02
Mechanism of action
Opsonization, complement activation, neutralization
03
Biological functions
Bacterial surface antigenElicits antibody responseContributes to bacterial virulenceDetermines bacterial serotype
04
Disease associations
InfectionSepsisBacterial pathogenesis
05
Safety considerations
Antigenic variation limits vaccine effectivenessPotential for antibody-dependent enhancement (ADE)Cross-reactivity with host glycans
06
Interacting drugs
Anti-O-antigen antibodies
1 more in the full profile.
07
Biomarkers
Anti-O-antigen antibody titerPresence of specific O-antigen serotype
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