Target intelligence / Profile preview

Bacterial Peptidoglycan Synthase FtsI (FtsI)

Target: FtsI
Molecular classification: Enzyme, Transpeptidase, Penicillin-Binding Protein (PBP)

Overview

FtsI, also known as penicillin-binding protein 3 (PBP3), is an essential bacterial cell division protein. It functions as a transpeptidase that catalyzes the cross-linking of peptidoglycan strands in the cell wall at the division septum during cytokinesis. This activity is crucial for maintaining cell shape and integrity during bacterial proliferation. It is inhibited by β-lactam antibiotics.

Other names: Penicillin-binding protein 3PBP3

Mechanism of action

β-lactam antibiotics inhibit FtsI by irreversibly acylating the active site serine residue, blocking cell wall synthesis.

Biological functions

Peptidoglycan synthesisCell wall biosynthesisBacterial cell divisionTranspeptidation

Disease associations

Infection

Safety considerations

Development of antibiotic resistance

Interacting drugs

β-lactam antibiotics

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