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Bacterial Membrane (Disruption of Membrane Potential)
- Molecular classification
- Lipid Bilayer, Membrane
01
Overview
The bacterial membrane is a phospholipid bilayer embedded with proteins that serves as a selectively permeable barrier, regulating the movement of substances into and out of the cell. It is essential for energy generation, biosynthesis, secretion, and maintaining cell shape and division. Disruption of the membrane potential collapses the proton motive force, leading to loss of vital functions and cell death. Drugs targeting the bacterial membrane are valuable against drug-resistant bacteria.
- Other names
- Bacterial Cytoplasmic MembraneBacterial Plasma Membrane
02
Mechanism of action
Disruption of membrane potential, collapse of proton motive force (PMF)
03
Biological functions
Barrier functionEnergy generationBiosynthesisSecretionCell shape maintenanceCell divisionTransport
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects on mammalian cell membranesToxicity related to membrane disruption
06
Interacting drugs
Daptomycin
2 more in the full profile.
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