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Bacterial Replacement Therapies
- Molecular classification
- Live Biotherapeutic Product (LBP), Microbiome Modulator
01
Overview
Bacterial replacement therapies are therapeutic strategies that involve introducing beneficial or benign bacterial strains into a host environment to displace or outcompete pathogenic bacteria. This approach aims to restore microbial balance and prevent or treat various diseases by leveraging natural competition among microbial species within human microbiomes. Modalities include probiotics, fecal microbiota transplantation (FMT), and the use of engineered or selected niche competitors.
- Other names
- ProbioticsMicrobiota RestorationFecal Microbiota Transplantation (FMT)Engineered Niche CompetitorsSelected Niche CompetitorsMicrobiome Restoration
02
Mechanism of action
Competitive exclusion, direct antagonism (e.g., bacteriocin production), and/or immune modulation by introduced bacterial strains.
03
Biological functions
Competitive exclusion of pathogensDirect antagonism of pathogensImmune modulationRestoration of microbial diversityGut microbiota modulation
04
Disease associations
Clostridioides difficile infectionDental cariesOtitis mediaGastrointestinal infectionsInflammatory bowel disease (potential)Obesity (potential)Metabolic disorders (potential)Autoimmune diseases (potential)
05
Safety considerations
Potential for opportunistic infectionsStrain selection and pathogenicityLong-term safety and efficacyTransmission of antibiotic resistance genes (FMT)Immune response to introduced bacteria
06
Interacting drugs
Antibiotics (impacted by)
1 more in the full profile.
07
Biomarkers
Fecal microbial composition (for FMT)Absence of target pathogensRestoration of microbial diversity
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