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Bacterial ribosome (70S)

Molecular classification: Ribonucleoprotein complex

Overview

The 70S ribosome is a large ribonucleoprotein complex found in prokaryotes, including bacteria and archaea. It serves as the site for translation, decoding messenger RNA (mRNA) into polypeptides/proteins during protein synthesis. It is composed of a small 30S subunit (16S rRNA and ~21 proteins) responsible for decoding mRNA and a large 50S subunit (23S rRNA, 5S rRNA, and ~34 proteins) that catalyzes peptide bond formation. Many antibiotics exert their effects by binding specifically to either the small or large bacterial ribosomal subunit, thereby inhibiting translation.

Mechanism of action

Inhibition of translation

Biological functions

TranslationProtein synthesis

Disease associations

Infection

Safety considerations

Off-target effects on eukaryotic ribosomes (though less susceptible)Antibiotic resistance

Interacting drugs

Amikacin

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