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Bacterial Ribosome (70S Initiation Complex) (70S Ribosome)

Target: 70S Ribosome
Molecular classification: Ribonucleoprotein, Protein Synthesis Machinery

Overview

The bacterial ribosome is a large cytoplasmic nucleoprotein complex responsible for translating mRNA into proteins. Specifically, the 70S initiation complex refers to the assembly formed at the start of translation, where the 30S and 50S subunits join with initiator tRNA and mRNA to begin polypeptide synthesis. This complex is a prime target for antibacterial drugs.

Other names: Prokaryotic Ribosome70S Initiation ComplexBacterial Translation Machinery

Mechanism of action

Inhibition of bacterial protein synthesis

Biological functions

Translation InitiationProtein SynthesismRNA BindingtRNA BindingReading Frame Maintenance

Disease associations

Infection

Safety considerations

Off-target effects on mitochondrial ribosomesDevelopment of antibiotic resistance

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