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Target intelligence / Profile preview
Bacterial Ribosome Subunit Binding tRNA (N/A)
- Target
- N/A
- Molecular classification
- RNA-protein complex, Ribonucleoprotein
01
Overview
The bacterial ribosome is a complex macromolecular machine responsible for translating mRNA into proteins. tRNA molecules bind to specific sites (A, P, and E) on the 30S and 50S ribosomal subunits to facilitate the addition of amino acids to a growing polypeptide chain. The bacterial ribosome is a major target for antibiotics.
- Other names
- Bacterial Ribosome70S Ribosome30S Subunit50S SubunitAminoacyl-tRNA binding sitePeptidyl-tRNA binding siteExit-tRNA binding siteA-siteP-siteE-site
02
Mechanism of action
Inhibition of bacterial protein synthesis by disrupting tRNA binding to the ribosome.
03
Biological functions
Protein synthesisTranslationmRNA decodingtRNA binding
04
Disease associations
Infection
05
Safety considerations
Off-target effects in eukaryotic cells (mitochondria)Antibiotic resistanceGastrointestinal distress
06
Interacting drugs
Tuberactinomycins
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