Bacterial toxins and inflammatory plasma components

Bacterial toxins and inflammatory plasma components represent the primary drivers of systemic inflammatory response syndrome (SIRS) and sepsis-induced organ failure (Source: NIH, StatPearls - Sepsis). This target group includes pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharides (endotoxins) and various pro-inflammatory cytokines like TNF-alpha and IL-6 (Source: PubMed, PMID: 30217904). The therapeutic use of donor neutrophil granulocytes aims to clear these substances from the blood through innate immune mechanisms, including phagocytosis and the release of antimicrobial peptides (Source: UniProt - Neutrophil Elastase). This approach is typically reserved for patients with severe sepsis or life-threatening infections where standard treatments have failed. By reducing the circulating levels of these toxins and mediators, the therapy seeks to stabilize the patient's hemodynamic status and prevent further tissue damage (Source: PubMed, PMID: 25133324). Monitoring efficacy typically involves measuring systemic inflammatory biomarkers like C-reactive protein and procalcitonin. Safety concerns include the risk of transfusion-related acute lung injury and potential alloimmunization against donor cells.

Other names

EndotoxinsExotoxinsPro-inflammatory cytokinesPathogen-associated molecular patterns (PAMPs)Damage-associated molecular patterns (DAMPs)Septic mediators

Neutralization and clearance of circulating toxins and inflammatory mediators via phagocytosis, enzymatic degradation, and sequestration by donor-derived neutrophil granulocytes.