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Target intelligence / Profile preview
Baculoviral IAP Repeat Containing 5 (BIRC5)
- Target
- BIRC5
- Molecular classification
- Inhibitor of Apoptosis Protein (IAP)
01
Overview
Survivin, also known as Baculoviral IAP Repeat Containing 5 (BIRC5), is a protein that inhibits apoptosis and regulates cell division. It is highly expressed in most human tumors and fetal tissues, but rarely detectable in normal adult differentiated tissues, making it an attractive target for cancer therapy. Overexpression correlates with increased tumor proliferation, resistance to apoptosis, drug resistance, and poor prognosis. Several therapeutic strategies are under investigation, including antisense oligonucleotides, small molecule inhibitors, and immunotherapies.
- Other names
- Survivin antigenSurvivin
02
Mechanism of action
Antisense oligonucleotides targeting survivin mRNA; Small molecule inhibitors disrupting survivin function; Immunotherapies using survivin-derived peptides as antigens; Combination therapies sensitizing cancer cells to apoptosis via survivin inhibition.
03
Biological functions
Inhibition of apoptosisRegulation of mitosisCell cycle controlChromosomal segregation
04
Disease associations
Cancer
05
Biomarkers
Early cancer detectionMonitoring therapeutic response
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