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Target intelligence / Profile preview
Baculoviral IAP Repeat-Containing Protein 2 (cIAP1)
- Target
- cIAP1
- Molecular classification
- E3 ubiquitin ligase, Inhibitor of Apoptosis Protein (IAP)
01
Overview
Baculoviral IAP repeat-containing protein 2 (BIRC2), also known as cIAP1, is a multifunctional protein that regulates apoptosis, inflammation, immunity, and cell signaling pathways. It inhibits apoptosis by interfering with caspase activation and functions as an E3 ubiquitin-protein ligase. It is implicated in cancer and autoimmune/inflammatory diseases, making it a potential therapeutic target.
- Other names
- API1MIHBIAP homolog BRING finger protein 48
02
Mechanism of action
Inhibition of caspase activation, E3 ubiquitin ligase activity, regulation of inflammatory signaling.
03
Biological functions
Apoptosis inhibitionUbiquitin-protein transferase activityRegulation of necroptosisPositive regulation of canonical NF-kappaB signal transductionModulation of inflammatory processesCell cycle regulationInnate immune response
04
Disease associations
CancerAutoimmune DiseasesInflammatory Diseases
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