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Target intelligence / Profile preview
Baculoviral IAP Repeat-Containing Protein 3 (cIAP2)
- Target
- cIAP2
- Molecular classification
- Inhibitor of Apoptosis Protein (IAP), E3 Ubiquitin Ligase
01
Overview
Baculoviral IAP repeat-containing protein 3 (cIAP2) is a key regulator of apoptosis, inflammation, and immunity. As an IAP family member, it inhibits caspase activation and functions as an E3 ubiquitin ligase. Its dysregulation is implicated in cancer progression, making it a potential therapeutic target for anticancer drug development targeting apoptotic resistance mechanisms.
- Other names
- API2Apoptosis inhibitor 2MALT2
02
Mechanism of action
Inhibition of caspase activation; modulation of TRAF1/TRAF2 signaling; E3 ubiquitin ligase activity.
03
Biological functions
Apoptosis inhibitionRegulation of NF-kappaB signalingE3 ubiquitin ligase activityModulation of inflammatory responsesRegulation of immunity
04
Disease associations
CancerInflammation
05
Safety considerations
Therapeutic resistance in cancerPotential for off-target effects due to broad signaling involvement
06
Biomarkers
Overexpression in various cancers
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