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Inhibitor of Apoptosis Protein Livin
- Molecular classification
- Inhibitor Of Apoptosis Proteins (IAPs), E3 ubiquitin ligase
01
Overview
Livin, also known as BIRC7, is a member of the inhibitor of apoptosis proteins (IAP) family. It plays crucial roles in regulating apoptosis, cell proliferation, and cell cycle control. Livin contains an N-terminal BIR domain that binds to caspases and a C-terminal RING finger domain with E3 ubiquitin ligase activity. It inhibits apoptosis by suppressing caspase activity and promoting the degradation of SMAC/DIABLO. Livin expression is generally low in normal adult tissues but is highly expressed in certain cancers, making it a promising therapeutic target.
- Other names
- BIRC7ML-IAPKIAPRNF50Baculoviral IAP repeat-containing protein 7Melanoma inhibitor of apoptosis proteinKidney inhibitor of apoptosis proteinRING finger protein 50
02
Mechanism of action
Inhibition of caspase activity; Promotion of SMAC/DIABLO degradation
03
Biological functions
ApoptosisCell proliferationCell cycle controlNegative regulation of caspase activityUbiquitination
04
Disease associations
CancerDrug Resistance
05
Safety considerations
Potential for off-target effects due to ubiquitination activityLimited expression in normal adult tissues (placenta exception) needs to be considered for safety during drug development
06
Biomarkers
Livin mRNA expression in cancer cells
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