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Target intelligence / Profile preview
Baculoviral IAP repeat-containing protein 8 (BIRC8)
- Target
- BIRC8
- Molecular classification
- Other (IAP family protein; not a receptor, enzyme, transporter, or classical drug target)
01
Overview
Baculoviral IAP repeat-containing protein 8 (BIRC8) is a member of the inhibitor of apoptosis protein (IAP) family, containing a baculoviral IAP repeat (BIR) domain and predicted E3 ubiquitin ligase activity. It is thought to protect against apoptosis mediated by BAX and promote protein ubiquitination, and is associated with negative regulation of apoptosis. However, functional and disease relevance in humans remain unclear—BIRC8 is listed as a pseudogene in some sources and does not appear to be a validated therapeutic target. The BIRC8 gene product is mainly found in the cytoplasm and nucleus and shares homology with other IAPs, which are well-known regulators of cell death[1][4][5][3].
- Other names
- Inhibitor of apoptosis-like protein 2IAP-like protein 2ILP2ILP-2hILP2RNF136Testis-specific inhibitor of apoptosis
02
Mechanism of action
Not established for BIRC8; general IAP antagonism is via disruption of caspase inhibition, but this has not been described for BIRC8 as a drug target
03
Biological functions
Negative regulation of apoptotic processUbiquitin ligase activityPositive regulation of Wnt signalingPositive regulation of protein ubiquitination
04
Disease associations
Cancer (noted in related literature for IAP family, but unclear for BIRC8 specifically)
05
Safety considerations
None known; no drugs in clinical trials target BIRC8 directly, so no safety profile is established
06
Interacting drugs
None known for BIRC8 specifically; general IAP inhibitors (such as SMAC mimetics) do not directly target BIRC8 (see notes below)
07
Biomarkers
None known for BIRC8 specifically
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