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Target intelligence / Profile preview
Baculoviral inhibitor of apoptosis repeat-containing protein 5 (Survivin)
- Target
- Survivin
- Molecular classification
- Inhibitor of Apoptosis (IAP), Oncoprotein
01
Overview
Survivin, encoded by the BIRC5 gene, is a key member of the inhibitor of apoptosis (IAP) family. It is highly expressed in most human tumors and embryonic/fetal tissues but nearly undetectable in normal adult differentiated tissues. Survivin functions both as an inhibitor of apoptosis and as a regulator of cell division, playing a critical role in cancer cell survival and proliferation. It promotes angiogenesis and is a validated therapeutic target in oncology.
- Other names
- BIRC5API4EPR-1Survivin
02
Mechanism of action
Inhibition of caspase activation, disruption of microtubule interaction at mitotic spindles, targeting of survivin as a tumor antigen.
03
Biological functions
Inhibition of ApoptosisCell Cycle RegulationMitosis RegulationAngiogenesis
04
Disease associations
CancerAutoimmune diseases (potential)
05
Safety considerations
Potential for off-target effects due to homology with other IAP proteins.Tumor-specific delivery is crucial to avoid impacting normal cell division.
06
Interacting drugs
Antisense oligonucleotides
2 more in the full profile.
07
Biomarkers
Survivin overexpression in tumor tissue
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