BAF chromatin remodeling complex subunit BCL7B (BCL7B)

BAF chromatin remodeling complex subunit BCL7B (BCL7B) is a highly conserved protein and a member of the BCL7 protein family, including BCL7A and BCL7C[2][3]. It functions as an integral component of the BAF (SWI/SNF) chromatin remodeling complexes, which are responsible for modulating chromatin structure and regulating gene expression[1][2]. BCL7B lacks well-defined functional domains beyond a short conserved N-terminal region, but it plays a significant role in chromatin remodeling, cellular differentiation, maintenance of nuclear structure, regulation of apoptosis, and the Wnt signaling pathway[2][3]. Loss or downregulation of BCL7B is implicated in cancer, particularly lymphomas and sarcomas, and frequently associated with reduced tumor suppressor activity and poor prognosis[2][3]. Additionally, BCL7B is often deleted in Williams-Beuren syndrome, which may contribute both to developmental phenotypes and increased cancer risk in this disorder[2][3]. While BCL7B is not itself a classical therapeutic target such as a receptor or enzyme, its importance as a chromatin remodeling factor and tumor suppressor makes it potentially relevant as a disease biomarker and indirect cancer treatment target[3].

Other names

B-cell CLL/lymphoma 7 protein family member BSMARCJ2BCL tumor suppressor 7BB-cell CLL/lymphoma 7BBAF complex component BCL7BBCL7B_HUMAN