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Target intelligence / Profile preview
BAF chromatin remodeling complex subunit BCL7C (BCL7C)
- Target
- BCL7C
- Molecular classification
- Chromatin remodeler subunit, BAF (SWI/SNF) complex subunit, Other
01
Overview
BCL7C is a protein-coding gene encoding a subunit of the BAF (also known as SWI/SNF) chromatin remodeling complex, which regulates chromatin accessibility and gene expression[3][4]. BCL7C shares sequence similarity with BCL7A and BCL7B but its precise biochemical and physiological functions remain incompletely defined[2][4]. Experimental evidence supports a tumor-suppressor role for BCL7C in ovarian cancer, specifically acting by inhibiting the transcriptional activity of mutant p53 and, consequently, repressing cancer cell proliferation and invasion in a mutant p53-dependent manner[2]. BCL7C may also have an anti-apoptotic function and participates in cellular gene regulation as part of the multi-subunit BAF chromatin remodeling complexes[3][4][5]. There are no known drugs or direct clinical biomarkers associated with BCL7C, although loss of BCL7C is linked to poor prognosis in certain cancers[2][4].
- Other names
- B-cell CLL/lymphoma 7 protein family member CSMARCJ3B-cell CLL/lymphoma 7CBCL tumor suppressor 7CBAF chromatin remodeling complex subunit BCL7C
02
Biological functions
Chromatin remodelingRegulation of gene expressionPossible anti-apoptotic roleTumor suppression (context-dependent)
03
Disease associations
Cancer (particularly ovarian cancer; tumor suppressor activity dependent on mutant p53)Lymphoma (genetic associations)Possible small-cell carcinoma of the ovary
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