BAH domain and coiled-coil containing protein 1 (BAHCC1)

BAH domain and coiled-coil containing protein 1 (BAHCC1) is a chromatin-associated protein characterized by a conserved bromo-adjacent homology (BAH) domain that specifically recognizes trimethylated histone H3 lysine 27 (H3K27me3)[1][3]. Through interaction with H3K27me3, BAHCC1 acts as a transcriptional corepressor, enforcing gene silencing of Polycomb target genes. It recruits additional repressive cofactors and links H3K27me3 recognition with histone deacetylation through interaction with HDACs, modulating chromatin structure and gene expression. BAHCC1 is overexpressed in some cancers (notably acute leukemia), and its depletion can derepress tumor suppressor and differentiation genes, highlighting its role in oncogenesis. Animal studies show that functional disruption of BAHCC1 interferes with normal development, underlining its crucial role in cell fate determination and chromatin organization[1][3][5][6].

Other names

BAH and coiled-coil domain-containing protein 1BAHD2KIAA1447BAH domain-containing protein 2bromo adjacent homology domain-containing protein 2BAHCC1

Drugs or molecules would be expected to act as inhibitors or disruptors of BAHCC1's interaction with H3K27me3 or associated corepressor complexes (mechanism characterized structurally and biochemically, but no current approved drugs)[1].