Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Bardet-Biedl Syndrome 1 Protein
- Molecular classification
- Protein, BBSome component, Ciliogenesis-related protein
01
Overview
Bardet-Biedl syndrome 1 protein (BBS1) is a core component of the BBSome complex, which is essential for the formation and function of primary cilia. It plays a critical role in sorting specific membrane proteins to primary cilia, regulating intracellular signaling pathways, influencing cell migration, and tissue repair. Mutations in BBS1 disrupt normal ciliogenesis and receptor trafficking, leading to the multisystemic symptoms characteristic of Bardet–Biedl syndrome.
- Other names
- BBS2L2Bardet-Biedl syndrome 1
02
Biological functions
CiliogenesisMembrane protein traffickingReceptor traffickingSignal transductionCell migrationTissue repair
03
Disease associations
Bardet-Biedl SyndromeCiliopathyRetinitis pigmentosaObesityKidney dysfunctionPolydactylyBehavioral dysfunctionHypogonadism
04
Safety considerations
Multisystemic effects due to pleiotropic functions in ciliogenesis and trafficking.Genetic heterogeneity complicates therapeutic targeting.Potential for off-target effects due to broad role in protein trafficking.
Beyond the preview
Go deeper on Bardet-Biedl Syndrome 1 Protein.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Bardet-Biedl Syndrome 1 Protein.